Track Matrixyl in Peptimes™
Matrixyl (palmitoyl pentapeptide-4, Pal-KTTKS) is the peptide Lys-Thr-Thr-Lys-Ser with a palmitoyl (fatty-acid) chain attached. FDA's substance registry also lists it as palmitoyl pentapeptide-3. (Source: FDA's substance registry (GSRS).)
Is Matrixyl FDA-approved?
No. Matrixyl isn't FDA-approved, and Drugs@FDA lists no application with it as an active ingredient.
Matrixyl
Also: palmitoyl pentapeptide-4, Pal-KTTKS, palmitoyl pentapeptide-3
- Status label in the Peptimes Library
- Not FDA-Approved
- Routes in Peptimes
- Topical
- Updated
- 1 Nov 2026
US regulatory status
What studies have looked at
Each point says who or what was studied and what the study reported, with its source and the date we checked it. These are findings from the sources cited, not advice or a promise of any result.
- In humans
In a 12-week double-blind, placebo-controlled split-face study in 93 women aged 35 to 55, a moisturiser with pal-KTTKS reduced wrinkles and fine lines more than the same moisturiser without it, on image analysis. The authors worked for Procter & Gamble.
Source: PMID 18492182, checked 1 Nov 2026
How to track it in Peptimes
Add Matrixyl in My Protocols and set the schedule you already follow: days of the week, times of day and a start date. Peptimes never suggests an amount when you log or schedule a dose. Its Library entry shows the status label “Not FDA-Approved”.
- Logging: the amount you applied and how you feel. It’s logged as topical, so there’s no injection site to record.
- Reminders and history: reminders at your times, Dose History, the Calendar and CSV or JSON export work as described on the peptide tracker app page.
Peptimes is a tracking app, not medical advice. Talk to a licensed clinician about your treatment. Peptimes doesn’t sell Matrixyl or any other compound.
More sources
- FDA, Global Substance Registration System, Palmitoyl pentapeptide-4, checked 1 Nov 2026: its structure and the names Matrixyl, Pal-KTTKS and palmitoyl pentapeptide-3.