Is Cyclic Glycine-Proline FDA-approved?

No. Cyclic glycine-proline isn't FDA-approved, and Drugs@FDA lists no application with it as an active ingredient.

Checked 1 Nov 2026. The sources are below.

Cyclic Glycine-Proline

Also: cGP, cyclo(Gly-Pro), cyclo(prolylglycyl), cycloprolylglycine

Status label in the Peptimes Library
Not FDA-Approved
Routes in Peptimes
SubcutaneousIntramuscularOralSublingualNasalTopicalOther
Updated
1 Nov 2026

US regulatory status

  • FDA status

    Not FDA-Approved. Drugs@FDA lists no application with cyclic glycine-proline (cyclo(prolylglycyl)) as an active ingredient.

    Source: Drugs@FDA, checked 1 Nov 2026

What studies have looked at

Each point says who or what was studied and what the study reported, with its source and the date we checked it. These are findings from the sources cited, not advice or a promise of any result.

  • In humans

    An observational study of 34 people after a stroke and 50 controls: the body's own plasma cGP and cGP/IGF-1 ratio were lower in patients and rose as they recovered, and the ratio at admission correlated with stroke-scale scores at day 90.

    Source: PMID 31019991, checked 1 Nov 2026

  • In animals or the lab

    cGP improved recovery from ischaemic brain injury in rats and inhibited lymphoma growth in mice. In cell culture it raised IGF-1 activity when IGF-1 was insufficient and lowered it when IGF-1 was excessive.

    Source: PMID 24633053, checked 1 Nov 2026

  • In animals or the lab

    In APP/PS1 mice, a model that develops amyloid plaques and memory impairment, cGP improved spatial memory and reduced amyloid plaque burden.

    Source: PMID 36909366, checked 1 Nov 2026

How to track it in Peptimes

Add cyclic glycine-proline in My Protocols and set the schedule you already follow: days of the week, times of day and a start date. Peptimes never suggests an amount when you log or schedule a dose. Its Library entry shows the status label “Not FDA-Approved”.

  • Routes: the app lets you record whichever route you used; none is established. Its routes are subcutaneous, intramuscular, oral, sublingual, nasal, topical and Other.
  • Logging: the amount you took, the route and how you feel.
  • Injection sites: subcutaneous and intramuscular doses record the site, and Insights shows where you’ve injected and how recently. It never suggests where to inject next. Other routes skip this step.
  • Reminders and history: reminders at your times, Dose History, the Calendar and CSV or JSON export work as described on the peptide tracker app page.

Peptimes is a tracking app, not medical advice. Talk to a licensed clinician about your treatment. Peptimes doesn’t sell cyclic glycine-proline or any other compound.

More sources

  • FDA, Global Substance Registration System, Cyclo(prolylglycyl), checked 1 Nov 2026: its formula and the names cyclic glycine-proline and cGP.
  • FDA, Drugs@FDA, checked 1 Nov 2026: no application lists cyclic glycine-proline as an active ingredient.

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