Is Argireline FDA-approved?

No. Argireline isn't FDA-approved, and Drugs@FDA lists no application with it as an active ingredient.

Checked 1 Nov 2026. The sources are below.

Argireline

Also: acetyl hexapeptide-8, acetyl hexapeptide-3, Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2

Status label in the Peptimes Library
Not FDA-Approved
Routes in Peptimes
Topical
Updated
1 Nov 2026

US regulatory status

  • FDA status

    Not FDA-Approved. Drugs@FDA lists no application with Argireline (acetyl hexapeptide-8) as an active ingredient.

    Source: Drugs@FDA, checked 1 Nov 2026

What studies have looked at

Each point says who or what was studied and what the study reported, with its source and the date we checked it. These are findings from the sources cited, not advice or a promise of any result.

  • In humans

    In a randomised, placebo-controlled study in 60 Chinese adults, eye-area wrinkles improved more with argireline than with placebo, on both a subjective rating and skin-replica measurements.

    Source: PMID 23417317, checked 1 Nov 2026

  • In animals or the lab

    In lab tests, argireline interfered with the SNARE protein complex that nerve cells use to release signalling chemicals. It inhibited that release with a potency similar to botulinum toxin A, but far less effectively.

    Source: PMID 18498523, checked 1 Nov 2026

How to track it in Peptimes

Add Argireline in My Protocols and set the schedule you already follow: days of the week, times of day and a start date. Peptimes never suggests an amount when you log or schedule a dose. Its Library entry shows the status label “Not FDA-Approved”.

  • Logging: the amount you applied and how you feel. It’s logged as topical, so there’s no injection site to record.
  • Reminders and history: reminders at your times, Dose History, the Calendar and CSV or JSON export work as described on the peptide tracker app page.

Peptimes is a tracking app, not medical advice. Talk to a licensed clinician about your treatment. Peptimes doesn’t sell Argireline or any other compound.

More sources

  • FDA, Global Substance Registration System, Acetyl Hexapeptide-8 Amide, checked 1 Nov 2026: its sequence of six amino acids and the names Argireline, acetyl hexapeptide-8 and acetyl hexapeptide-3.

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